The San Francisco 49ers enter Week 13 in pursuit of a win to snap their current two-game losing streak and for a win that can help ignite them during the season’s stretch run.
San Francisco will have to successfully invade one of the NFL’s most hostile venues in order to do so. The 49ers (5-6) travel to the Buffalo Bills (9-2) for a prime time showdown.
San Francisco is expected to see the return of starting quarterback Brock Purdy. Purdy missed the 49ers’ 38-10 loss last week at Green Bay with a right shoulder injury.
With San Francisco fighting to stay in the NFC West race and Buffalo looking to stay within a game of Kansas City for the AFC’s No. 1 seed, here’s a look at the latest game day odds, including the point spread, point total and the respective injury reports.
49ers vs. Bills game odds:
All NFL Odds via BetMGM:
- Point spread: Buffalo -6
- Money line: Buffalo -275, San Francisco +225
- Over-under: 44.5
49ers vs. Bills injury updates:
- San Francisco DE Nick Bosa – OUT (hip, oblique)
- San Francisco DT Jordan Elliott – OUT (concussion)
- San Francisco LB Dre Greenlaw – OUT (Achilles)
- San Francisco CB Deommodore Lenoir – OUT (knee)
- San Francisco OT Trent Williams – OUT (ankle)
- San Francisco LG Aaron Banks – OUT (concussion)
- Buffalo TE Dalton Kincaid – OUT (knee)
- Buffalo WR Keon Coleman – Questionable (wrist)
49ers vs. Bills prediction, pick
San Francisco is still looking to get running back Christian McCaffrey back to his full NFL Offensive Player of the Year form following his return from injury. Maybe there’s some flashes of that in this contest.
The return of Purdy should help, but, ultimately, the injury list elsewhere just feels too long and too significant for San Francisco to overcome on the road against one of the NFL’s best teams and best quarterbacks.
Prediction: Buffalo 30, San Francisco 20
49ers vs. Bills channel, start time, streaming:
The 49ers vs. Bills game starts at 5:20 p.m. PT and can be seen on NBC and streamed on Peacock.
Get more betting analysis and predictions at Sportsbook Wire.
About the Author: Insidethe49
