The San Francisco 49ers will finish their preseason schedule Friday against the Las Vegas Raiders at Allegiant Stadium.

One of the reasons for optimism about the 49ers entering the offseason revolved around their lack of high-profile roster turnover. They lost a couple key players, but their starting groups were on track to look mostly the same as a last year when they went to the Super Bowl.

Now, with the preseason winding down and the proverbial rubber rapidly approaching the metaphorical road, things have changed a little bit. Contract talks, injury issues and training camp performances have pushed a handful of starting roles into a more uncertain realm.

Here are five starting spots that are still question marks as the 49ers get set to wrap up their preseason Friday night:

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