The San Francisco 49ers have been dealing with injury issues all season, but Week 12’s game against the Green Bay Packers feels like a different mountain to climb.

In Week 12 the 49ers have already ruled out quarterback Brock Purdy and defensive end Nick Bosa. Left tackle Trent Williams missed a full week of practice and is officially questionable.

That trio would be at or near the top of a list of the 49ers’ most important players. Missing any two of them would have been a nightmare. The potential of missing all three puts San Francisco into a spot where their depth may be tested beyond its limits.

If San Francisco is to swing an upset in Green Bay, they’ll need these six players to step up:

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