Sunday’s 33-17 loss for the 49ers felt like a new low for the 2021 season, which is pretty impressive considering some of the adversity they’ve faced. Falling at home to a shorthanded Cardinals team without their starting quarterback isn’t something that’ll be easy to recover from.

With the 49ers now sitting at 3-5 and searching for answers after another bad loss, we had some big-picture takeaways that’ll matter down the stretch:

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